This post was originally published on the Poseidon Blog

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So, you’ve ordered your food, now what?

Often, we want to summarise the genetic data through summary statistics. Examples for such summary statistics are F-Statistics. Our tool xerxes fstats, which is part of the Poseidon ecosystem, provides a powerful and expressive tool to compute such summary statistics from genetic data described in Poseidon packages.

This post was originally published on the Poseidon Blog

Image credit by Unsplash

Today we’re releasing a new major release for trident, our command-line tool and workhorse for working with Poseidon packages.

If you haven’t checked it out yet, take a look at our documentation. With trident, you can download packages from our web-server, initialise new packages, perform validations, list summaries of packages, and - most importantly - forge new packages out of existing ones. This functionality, forge is more than a merge, and more than a subset tool. It is both. Perhaps a working analogy for what it does is a restaurant. At a restaurant, you order a specific meal, but you don’t care how the ingredients have been packaged, and with which other ingredients they are stored. You just want the chefs to assmble the meal, no matter whether the beans are stored together with the peas or not.

I recorded two Podcast episodes (in German) in Luca Beutel’s fabulous Show “Inspirierend anders”.

First Episode: Apple Podcasts, Google Podcasts and Spotify.

Second Episode: Apple Podcasts, Google Podcasts and Spotify.

Victoria Gibbon from University of Cape Town wrote a nice article piece about our project on the Sutherland Nine, which we published earlier this year.

On March 16, 2023, I participated in a panel discussion about the topic of “What is saxonian” in at the Deutsche Hygiene-Museum in Dresden, Germany. There is now a short video available on Youtube.

We are honored for having been nominated as one of the projects that can be voted on as “Research Project of the Year 2023” in this year’s Current Archaology Awards”

Alongside our recent publication on early medieval ancient DNA from England, we are honored to having been invited to be featured in a Special Issue of the magazine “Current Archaeology”.

Command line tools are essential in many computational fields of science, not the least because command lines are often the only interface on a high-performance compute cluster or server. Particularly critical in command-line tools is a well-defined interface between the user and the program, the command line interface (CLI). A command line interface is like a contract. The user promises to provide input parameters in the right shape and type, and the tool promises to work with this input the way it is expected to. A breach of contract from the caller may result - at best - in a refusal of the program to run, and at worst in undefined behavior.

I have finally gotten around to install DISQUS on my webpage’s blog posts. When you view my blog, you will now find below every post a section where you can comment and discuss with other users via DISQUS. DISQUS is an online tool that provides discussion forum-like capabilities to any webpage. It’s an awesome service that spares webpage authors the annoyance of having to provide a database and fully fledged backend usually required to provide user-management and forum-functionality.

An Interview with Stephan Schiffels has been published on the EOSC website.

Two PhD students from my group will present at this years 26th Annual Meeting of the European Association of Archaeologists (EAA) from August 24-30.

I gave a talk at the TEDxTHBrandenburg, which you can now enjoy on Youtube.

We are engaged in a one-of-a-kind project on the genetic analyses of the Sutherland Nine.

I recently rebuilt my website. I had previously used Wordpress, and while that was perfect to get started, I soon got annoyed by its relative inflexibility. While Wordpress has a huge community with tons of free templates for nicely designed websites, the templates themselves are often very opinionated in a sense that they encourage certain archetypes, like Blogging sites, or magazine-style sites. Customization is possible, but it comes in the form of plugins (again, thousands are available for free), and the more customization you want, the more plugins you end up using. This at some point makes the whole system a bit bloated, and still not quite right in the end.

Stephan Schiffels’ project MICROSCOPE will investigate the pre-Roman European Iron Age with new genetic methods. The challenge in most periods of European prehistory since the Bronze Age is a high degree of genetic homogeneity among European populations. This is due to millennia of mixing and amalgamation of the originally diverse ancestry lines that make up Europeans today. In order to address this, a significant part of the project is devoted to the development of new statistical genomic methods, based on shared rare genetic variation, which will help investigating the subtle population dynamics needed to infer population movements in the past.

Working in academia comes with unique freedoms and challenges. I would argue that in no other job we have so much freedom to define our own work. At least at the Post-doctoral level and beyond, you mostly can choose what problems you want to work on, how to solve them, and in what pace. Even as a PhD student, in many cases there is a lot of freedom to choose projects and set your own goals and deadlines (this may not be the case for everybody, but it was for me).

A Webinar that I gave to the Regional Student Group of Turkey is available on Youtube.

A brief interview with me on our newly published study on Paleo-Inuit genetic history of the North-Ameerican arctic appeared today on German television.

This post appeared originally on the Nature Ecology & Evolution Community blog.

Reference: https://www.nature.com/articles/s41586-019-1251-y

In October 2015 — I had just started my new job as Group Leader at the newly founded Max Planck Institute for the Science of Human History in Jena, Germany — we were visited by a young researcher, Pavel Flegontov, from Ostrava University in Czech Republic. Pavel is a computational biologist who a few years ago got himself interested in human population genetics and prehistory. I was at the time about to publish our paper on Anglo-Saxon ancient DNA from England, for which we developed new methodology to investigate fine-scale population structure based on rare genetic variation. Pavel wanted to apply this new methodology to an open genetic question in the literature about Athabaskans, an ethnic group from North America. David Reich, a geneticist from Harvard University, had shown previously in a paper in 2012 that Athabaskans have a distinct ancestry component not shared with many other Native Americans and which could be related to Paleo-Eskimos.

A short interview with me on genetic ancestry testing (in German) appeared on German radio today.

I’m excited to announce that there are now three talks from my group at the upcoming EMBO | EMBL Symposium on Reconstructing the Human Past – Using Ancient and Modern Genomics. My students Ke Wang and Joscha Gretzinger both have their abstracts accepted for a talk at the symposium. Congratulations!

We recently advertised 16 new PhD positions within our newly founded Max Planck Research School for the Science of Human History, an institution tied both to the University of Jena and the Max Planck Institute for the Science of Human History in Jena.

(Cross-posting from the original ad at the MPI-SHH Webpage, offline now)

The MPI-SHH pursues an integrative approach to the study of human history. “Hard” facts as bones, teeth, plants, stones and “soft” facts as languages, history, or religions can say a lot about human history. It is our task to understand and interpret them. The International Max Planck Research School for the Science of Human History (IMPRS-SHH) is seeking for researchers knowing well how to decode such facts and data and looking for new ways of decoding them. The IMPRS-SHH is a cooperation of the Max Planck Institute for the Science of Human History and Friedrich Schiller University, both situated in Jena, a traditional as well as a modern university town in the heart of Germany. The IMPRS-SHH is offering 16 PhD positions for 14 projects.

Vorhersagen von Wahlergebnissen aufgrund von Umfragen gehören zum Standardgeschäft des politischen Betriebes. Etwa wöchentlich veröffentlichen die großen Fernsehsender Umfragen, zum Beispiel zur sogenannten “Sonntagsfrage”: “Wenn am nächsten Sonntag Bundestagswahl wäre, wen würden Sie wählen?”

So, I am reading this book called “Probability Theory; The logic of Science” by E.T. Jaynes. It is an excellent read, highly recommended, and quite an eye-opener to me in terms of understanding statistics and data analysis from first principles. Here I am sharing a few particularly interesting insights from chapter 9.11 (“Significance Tests”, p. 293).

In my last blog post I have shown how we estimated the Anglo-Saxon genetic contribution to modern English from rare variants. Here I’ll show more generally how we can use rare genetic variants to learn more details about population history.

Human history is deeply imprinted in our genomes, through patterns of common ancestry. These patterns can be studied by looking at mutations that are shared between people living in different times in different places. In this post I will summarize our recent genetic study on Anglo-Saxon immigration history in Britain, and in doing so,will describe some new methodology that we have developed for this project, which is based on rare mutations.

This is a response to this creationist’s post on Human evolution, in which I found so many flaws that I have to at least correct the most obvious factual errors for general readers. At the same time, this may serve as a quick primer into neutral theory.